Strategic Histopathology for Research

Non-clinical histopathology services and consultation for discovery and efficacy.
Contact Us

Research Areas

Evaluations and analyses tailored to answer the questions most important to your study. As a full-service lab, we help you design a custom set of endpoints integrating qualitative and quantitative methods.
Fibrosis
Cell / Gene Therapy
Colitis
Inflammation /Immunology
Cardiovascular Disease
Metabolic Disease
Oncology
Safety
Translational Research
Model Development

Fibrosis

Colonic Fibrosis / Fibrostenosis
  • Mural vs Mucosal Collagen Quantification
  • Regional Inflammation Scoring/Quantification
  • Colitis Scoring (Gland Injury, Erosion, Hyperplasia, Inflammation)
  • Epithelial Proliferation Quantification
  • Pro-Fibrotic, Pro-Inflammatory Protein/RNA Quantification
Dermal Fibrosis
  • Epidermal Hyperplasia Morphometrics
  • Dermal Fibrosis Quantification
  • Myofibroblast+Vascular Quantification
  • Inflammation Scoring/Quantification
  • Pro-Fibrotic, Pro-Inflammatory Protein/RNA Quantification
Hepatic Fibrosis
  • Collagen + Myofibroblast Quantification
  • Proliferation Quantification
  • Inflammation Scoring/Quantification
  • Pro-Fibrotic, Pro-Inflammatory Protein/RNA Quantification
  • Hepatocyte Necrosis
  • Bile Duct Hyperplasia
Idiopathic Pulmonary Fibrosis
  • Modified Ashcroft Scoring
  • Collagen Quantification
  • Inflammation Scoring/Quantification
  • Pro-Fibrotic, Pro-Inflammatory Protein/RNA Quantification
Renal Fibrosis
  • Collagen + Myofibroblast Quantification
  • Inflammation Scoring/Quantification
  • Tubular Injury Scoring or Quantification (KIM1)
  • Pro-Fibrotic, Pro-Inflammatory Protein/RNA Quantification
Systemic Sclerosis/Scleroderma
  • *Assessed by organ submitted
  • Collagen Quantification
  • Pro-Fibrotic, Pro-Inflammatory Protein/RNA Quantification
  • Myofibroblast+Vascular Quantification

Cell / Gene Therapy

Cell / Gene Therapy
  • Efficacy Analysis
  • Biodistribution (Protein/RNA Scoring/Quantification)
  • Safety Evaluation

Colitis

General Assessments
  • Inflammation Scoring/Quantification
  • Gland Injury
  • Erosion
  • Hyperplasia/Epithelial Proliferation Quantification
  • Crypt/Villus Morphometrics
  • Goblet Cell Quantification
Inflammation
  • Regional Inflammation Scoring/Quantification
  • Regional Quantification of Discrete Inflammatory Cell Populations
Fibrostenosis
  • Collagen + Myofibroblast Quantification
  • Proliferation Quantification
  • Inflammation Scoring/Quantification
  • Pro-Fibrotic, Pro-Inflammatory Protein/RNA Quantification
  • Hepatocyte Necrosis
  • Bile Duct Hyperplasia
Carcinogenesis
  • Polyp Morphometrics
  • Oncogene/Transcription Factor/Proliferation Protein/RNA Quantification

Inflammation / Immunology

Acute Lung Injury
  • American Thoracic Society ALI Scoring
  • Inflammation Scoring/Quantification
  • Pro-Inflammatory Protein/RNA Quantification
Acute Hepatitis
  • Hepatocyte Necrosis/Apoptosis Scoring/Quantification
  • Inflammation Scoring/Quantification
  • Proliferation Quantification
Arthritis
  • OARSI Scoring
  • Inflammation Scoring/Quantification
  • Pannus Scoring
  • Cartilage Damage Scoring/Morphometrics
  • Bone Resorption Scoring
  • Osteoclast Quantification
  • Pro-inflammatory, Arthrogenic Protein/RNA Quantification
Asthma
  • Inflammation Scoring/Quantification
  • Regional Quantification of Discrete Inflammatory Cell Populations(Eosinophils, Mast Cells, Lymphocytes)
  • Goblet Cell Hyperplasia Score/Quantification
  • Epithelial Cell Degeneration Score
  • Collagen Quantification
Atopic Dermatitis
  • Epidermal Hyperplasia Morphometrics
  • Epidermal Necrosis Scoring
  • Dermal Edema/Fibrosis Quantification
  • Inflammation Scoring/Quantification
  • Pro-Fibrotic, Pro-Inflammatory Protein/RNA Quantification
System Lupus Erythematosus
  • Glomerulonephritis Scoring/Morphometry
  • Inflammation Scoring/Quantification
  • Complement, Immunoglobulin Scoring/Quantification
  • Vasculitis Scoring
  • Tubular Injury Scoring
  • Lymphoid Population Quantification
  • *Assessed by organ submitted
Celiac
  • Inflammation Scoring/Quantification
  • Intra-Epithelial Lymphocyte Quantification
  • Crypt/Villus Morphometrics
  • Crypt Injury/Necrosis
Graft vs Host Disease
  • Inflammation Scoring/Quantification
  • Intra-Epithelial Lymphocyte Quantification
  • Epithelial Morphometrics
  • Necrosis/Apoptosis Scoring/Quantification
  • Collagen Quantification
  • *Assessed by organ submitted
Multiple Sclerosis (EAE)
  • Inflammation Scoring/Quantification
  • Demyelination Scoring/Quantification
  • Gliosis Quantification

Cardiovascular Disease

Pulmonary Hypertension
  • Vascular Wall Thickness Morphometrics
  • Arteriole Muscularization and Obstruction Classification
  • Arterialization (Type II PH)
  • Pulmonary Inflammation Scoring/Quantification
  • Vasculitis Scoring
  • Ashcroft Scoring (Type III PH)
  • Cardiac Inflammation/Collagen Scoring/Quantification
Atherosclerosis
  • Plaque Area/Luminal Occlusion Morphometrics
  • Plaque Classification AHA
  • Inflammation Scoring/Quantification
  • Intraplaque Vessel Scoring/Quantification
  • Thrombosis/Recanalization Scoring
Cardiomyopathy
  • Cardiomyocyte Degeneration/Necrosis Score
  • Cardiomyocyte Morphometrics
  • Inflammation Scoring/Quantification
  • Collagen Quantification
  • Microvascular Density Quantification
Myocardial Infarction
  • Infarct Area Morphometrics
  • Collagen Quantification
  • Microvascular Density Quantification
  • Inflammation Scoring/Quantification

Metabolic Disease

MASH/MASLD
  • Steatosis Quantification
  • Lipid Composition Quantification
  • NAS Scoring
  • Regional Fibrosis Quantification
  • Inflammation Quantification
Alcoholic Liver Disease
  • Steatosis Scoring/Quantification
  • Inflammation Scoring/Quantification
  • Hepatocyte Necrosis Scoring/Quantification
Storage Diseases
  • Inclusion/Accumulation Quantification
  • Inflammation Scoring/Quantification
  • Necrosis/Apoptosis Scoring/Quantification

Oncology

Oncological Endpoints
  • Descriptive Pathology (Differentiation and Morphology)
  • Regional Inflammation Quantification
  • Necrosis/apoptosis Quantification
  • Proliferation Quantification
  • Microvascular Density Quantification
  • Tumorigenesis Protein/RNA Quantification
  • H-scoring
  • Metastasis Evaluation

Safety

Safety
  • Toxicologic Pathology Evaluation by ACVP-board certified veterinary pathologists
  • Integration of in vivo, clinical pathology, and macroscopic findings with microscopic findings
  • Evaluation/Quantification of supporting histochemical stains, protein, or RNA

Translational Research

Translational Research
  • MD Pathology Evaluation of Research/Non-Clinical Human Tissue
  • Inflammation Scoring/Quantification
  • Assessment of model translation to human disease
  • Integration of human-animal comparative pathology

Model Development

Model Development
  • Support for the development of animal models of human disease
  • Team of scientists and pathologists support model development
  • Guidance in model selection based on desired clinical and microscopic features
  • Analytical endpoint selection for assessing model success
  • Development of necessary supporting assays including immunohistochemistry or in situ hybridization, and quantification

New to Pathology? We’ve Got Your Back!

Our pathologists are here for you from the very start, ensuring a seamless experience and a deep understanding of your goals.
You’ll work with the same pathologist from day one, ensuring a seamless experience and a deep understanding of your goals.
Talk With The Team

Have Materials? We accept:

Tissue
Tissue
Blocks
Blocks
Slides
Slides
Images
Images

Don't have materials, but have questions?

Let’s Chat!

Resources

Steatosis Scoring and Quantification in a Mouse Model of MASH
Male mice were fed control or Gubra-Amylin NASH (GAN) diet for at least...
Sample Preparation Best Practices
February 6, 2025
List of Targets
Explore our library of special stains and protein/RNA/DNA target lists.
FAQs
We've compiled a list of out more frequently asked questions regarding necropsies, histology/advanced staining techniques, and our pathology+quantification approach.

Hey, Boston!

DTR Labs is local to Boston and we're excited! Check out our additional service offerings to Boston locals:
Local In Boston
We're just outside Medford and have a dedicated team member ready to pick up your samples the same day
Sample Prep
Being local, we're able to assist you at necropsy with your sample collection and preparation for histology

About us

We believe forward-thinking conversations can start at any stage of the non-clinical development process (well before histopathology can be utilized), and wanted to extend a deeper guidance with greater collaboration.

That's why we focus on building a relationship with your team and program, offering a trusted perspective to help you navigate the complex non-clinical landscape.
DTR Labs, formerly known as Dallas Tissue Research (DTR), headquartered at its original space in Dallas, Texas, has grown to a geographically diverse team and underwent a name-shift to capture that. In addition to Dallas, DTR opened a sister lab located in the Boston-Metro area of Medford, Massachusetts in 2024.
More About Us